磁共振力显微镜

Magnetic resonance force microscope

磁共振力显微镜是磁共振成像技术与扫描探针显微术的成功结合,它同时具备了磁共振成像的三维探测能力与扫描探针显微术的纳米分辨能力。与传统的感应式磁共振信号探测方法相比,磁共振力显微镜的最大优势在于它采用的机械力学磁共振信号探测方法具有极高的信噪比,可以满足单个核自旋探测的要求。自1991年华盛顿大学的Sidles教授首次提出磁共振力显微镜的概念以来,其空间分辨率逐年提高,正逐步向单个生物大分子三维结构测定的目标迈进。本文结合作者研制磁共振力显微镜的工作与当前国际研究进展,阐述了磁共振力显微镜的基本原理,着重从仪器角度介绍了各个重要组成部分,并系统地讨论了磁共振力显微镜信号探测的主要技术方法。

By successfully combining the advantages of Magnetic Resonance Imaging（MRI） and Scan Probe Microscopy（SPM）,Magnetic Resonance Force Microscope（MRFM） possesses both three-dimension detection capacity of MRI and the high spatial resolution of SPM.Comparing with the inductive magnetic resonance detection technique,MRFM acquires most of its advantages from its mechanical magnetic resonance signal detecting method,which affords much higher signal to noise ratio（SNR） and allows direct observation of single electron spin and single unclear spin.Since first proposed in 1991,the spatial resolution of MRFM has been improved dramatically.With the keeping advance of its spatial resolution,the initial goal of imaging individual bio-molecule will finally be realized.In this paper,we concisely reviewed the development of MRFM and described the working principle of MRFM in details from instrumental aspect based on our research works.