抗抑郁药文拉法辛的合成研究

Studies on Synthesis of Antidepressant Venlafaxine

以苯甲醚为起始原料，采用新路线经傅克酰化、胺化、还原、溴代、格氏五步反应制得新型抗抑郁药文拉法辛（ｖｅｎｌａｆａｘｉｎｅ） ，总收率为１１ ％ ，反应原料易得，反应条件温和，后处理方便，适合工业化生产。

New antidepressant venlafaxine was a noradrenalin and 5 H T uptake inhibitor( S S R Is) with fewer side effectsthan tricyclic antidepressant drugs . In this paper , we reported the synthesis of venlafaxine by adopting a newroute via five steps with methoxybenzene as starting material. The total yield was 11 % and the term of reaction wasmoderate and suitable for a scale production .