脑损伤后炎症相关因子的变化及其临床意义

Dynamic changes and clinical significance of inflammatory factors in patients with acute craniocerebral injury

目的探讨急性颅脑损伤后患者血清中炎症相关因子的变化规律及其意义。方法选取我院收治的急性颅脑损伤后住院治疗患者88例,动态监测患者血清中IL-10、IL-8、TNF-α的水平,并进行统计学处理。结果急性颅脑损伤后患者的IL-10、IL-8、TNF-α的血清水平明显升高,且颅脑损伤的程度越严重,则损伤后即刻血清炎症因子的水平越高。结论急性颅脑损伤后患者血清炎症相关因子的水平高低可以作为患者伤情评价和判断预后的有效指标。

Objective To study the dynamic changes and clinical significance of inflammatory factors in patients with acute craniocerebral injury. Methods Dynamic measurement of TNF-α,IL-8,IL-10 in 88 patients with acute craniocerebral injury were performed and the date was analyzed statistically. Results The levels of TNF-α, IL- 8,IL-10 remarkably increased immediately after acute craniocerebral injury and the severer the craniocerbral injury, the higher the level of inflammatory factors. Conclusion The level of inflammatory factors in patients with acute craniocerebral injury can serve as a guideline for judging the injury degree and prognosis.