鼻咽癌组织中P120ctn、VEGF-C的表达及临床意义

Expression and clinical significance of P120ctn,VEGF-C in human nasopharyngeal carcinoma

目的探讨链蛋白P120(P120ctn)、血管内皮生长因子-C(VEGF-C)在鼻咽癌组织中的表达及意义。方法采用免疫组化二步法检测56份鼻咽癌(鼻咽癌组)和15份正常鼻咽黏膜(正常组)组织中P120ctn和VEGF-C的表达情况,并分析两者间及与鼻咽癌临床病理特征的关系。结果鼻咽癌组和正常组P120ctn异常表达率分别为67.86%6、.67%,VEGF-C阳性表达率分别为83.92%、26.6%,两两比较P均<0.05;P120ctn异常表达与鼻咽癌病理分型、TNM分期、颈部淋巴结转移相关,VEGF-C阳性表达与鼻咽癌TNM分期、颈部淋巴结转移相关;鼻咽癌组织中P120ctn与VEGF-C表达呈正相关。结论鼻咽癌的发生发展过程中常发生P120ctn和VEGF-C的表达异常,与肿瘤的浸润、转移有关,可作为判断鼻咽癌生物学特征和预后的重要指标。

Objective To investigate the expression and significance of P120 catenin（P120ctn）,vascular endothelial growth factor-C（VEGF-C） in human nasopharyngeal carcinoma.Methods Using immuno-histochemical technique to examine the expression of P120ctn,VEGF-C in 56 nasopharyngeal carcinoma cases（nasopharyngeal carcinoma group）and 15 normal mucous membrane of nasopharynx cases（normal group）,and the relations between P120ctn,VEGF-C and clinicopathological features were analyzed.Results P120ctn abnormal rate of the nasopharyngeal carcinoma group and normal group were 67.86%,6.67%,and VEGF-C positive expression rate were 83.92%、26.6%,both P〈0.05;the abnormal rate of P120ctn was correlated with the pathomorphological classification,TNM stage,cervical lymph node metastasis of nasopharyngeal carcinoma,and the positive rate of VEGF-C was correlated with the TNM stage and cervical lymph node metastasis of nasopharyngeal carcinoma;The expression of VEGF-C was positive correlated with P120ctn.Conclusions The abnormal expressions of P120ctn and VEGF-C in nasopharyngeal carcinoma usually occurred during the process of development and progression,which might be related with invasion and metastasis,and might be used as important signal of biological features and prognosis.