巨噬细胞替代激活及调控

Progress of Studies on Macrophage Alternative Activation and Its Regulation Mechanisms

巨噬细胞作为机体天然免疫系统的重要组成部分,在生物体内发挥多种免疫功能,包括吞噬细菌、病毒等微生物,递呈并处理抗原和参与免疫应答。这些免疫功能的发挥依赖于巨噬细胞的激活。巨噬细胞的激活有多种形式,包括经典激活与替代激活。研究表明,替代激活的巨噬细胞参与了组织修复、血管新生、肿瘤发展侵袭与转移、炎症干预等多种生理病理过程。本文将根据近年来的研究进展,就巨噬细胞替代激活的亚型、分子特征、相关信号转导通路及重要调控分子作一综述。

Macrophage is a vital component in innate immune system and plays immunological regulation roles by being bacterial phagocyte and antigen presenting process. Macrophage activation can be described as two forms, classical and alternative. Studies have shown alternative activated macrophage has been involved in many physiological and pathological functions such as tissue remolding, angiogenesis, tumor growth, development and metastasis, it：flammation resolution. In this review, we will summarize recent progresses of research in alternative activated macrophage, focusing on its category, phenotype, molecular markers, signaling pathway and important regulatory molecules.