脑血管病患者血浆中同型半胱氨酸的丰度及相关性研究

The relationship between plasma homocysteine levels and cerebrovascular disease

目的研究血浆中同型半胱氨酸(Hcy)的丰度在脑血管病患者中的分布及变化,观察它与脑血管病发生及其他相关危险因素间的关系。方法收集257例经临床及影像学确诊的脑血管病(包括脑梗死、脑出血、短暂性脑缺血发作)患者的临床资料,对其血浆Hcy水平与脑血管病发生及其他危险因素进行相关性研究,数据用SPSS13.0统计软件分析。结果脑梗死、脑出血、短暂性脑缺血发作(TIA)三组的Hcy水平明显高于正常对照组,高血压病、高脂血症与Hcy水平呈正相关,高Hcy血症与脑血管病发生呈显著正相关。结论高Hcy血症与脑血管病发生有关,是脑血管病的独立危险因素。

Objective To investigate the relationship between plasma homocysteine levels and cerebrovascular disease and the other risk factors.Methods The clinical data of 257 patients with cerebrovascular disease（including Cerebral Infarction,Cerebral Hemorrhage and TIA） was collected,the relationship between plasma homocysteine levels and cerebrovascular disease and the other risk factors was investigated and analysed using SPSS 13.0.Results The mean homocysteine levels of patients with Cerebral Infarction,Cerebral Hemorrhage and TIA were all significantly higher than that of the control group,and there was a positive correlation between homocysteine level and hypertension,hyperlipidemia.Conclusions Hyperhomocysteinemia has a significant positive association with cerebrovascular disease,and it was an independent risk factor of cerebrovascular disease.