FD-OCT、Visante OCT及A超角膜测厚仪测量人中央角膜厚度的比较

Comparison of central corneal thickness measured by Fourier domain optical coherence tomography,Visante optical coherence tomography and A ultrasound pachymetry

目的比较FD-OCT、Visante OCT及A超角膜测厚仪测量人中央角膜厚度的差异,为临床检查提供参考。方法 选取健康志愿者27人(54眼),依次用FD-OCT、VisanteOCT及A超角膜测厚仪测量双眼中央角膜厚度,三种仪器均测量3次,取其平均值,对所得数据进行统计学分析。结果 54眼志愿者中央角膜厚度测量结果:FD-OCT测量值为(530.74±31.74)μm,Visante OCT为(554.06±33.32)μm,A超为(531.61±31.76)μm。三种测量方法结果差异有统计学意义(F=9.053,P<0.01)。两两比较显示:FD-OCT测量结果与A超相比,差异无统计学意义(P>0.05);Visante OCT与A超相比,差异有统计学意义(P<0.05);Visante OCT和FD-OCT相比,差异也有统计学意义(P<0.05),但两种测量结果高度相关(r=0.949),前者所测中央角膜厚度较后者厚(23.32±10.46)μm,两者差值的95%可信区间为20.46～26.17μm。结论 A超作为目前角膜厚度测量的金标准,随着检查舒适度、检查速度等要求的提高,使用渐显局限。新的角膜测厚仪的出现,有望改善这些问题,但是诊断分析时需注意其可能带来的测量结果偏差。

Objective To compare the measurement differences of central corneal thickness（CCT） in normal eyes by Fourier domain optical coherence tomography（FD-OCT）,Visante optical coherence tomography and Aultrasound pachymetry.Methods CCT of 54 eyes from 27 normal volunteers was measured three times by FD-OCT,Visante OCT and A ultrasound pachymetry,respectively.The values determined by each technique were averaged for each eye and then statistically analyzed.Results Mean CCT measured by FD-OCT,Visante OCT and A ultrasound pachymetry were（530.74±31.74）μm,（554.06±33.32）μm and（531.61±31.76）μm,respectively.There was a significant difference in CCT measurements among the three techniques（F=9.053,P0.01）.However,no statistical difference between FD-OCT and A ultrasound pachymetry was observed（P0.05）,statistical differences between Visante OCT and A ultrasound pachymetry,FD-OCT（All P0.05）.Visante OCT and FD-OCT measurements were highly correlated（r=0.949）.Visante OCT values were a mean of（23.32±10.46）μm thicker than FD-OCT values,the 95% CI of difference was from 20.46 μm to 26.17 μm.Conclusions As the gold standard in corneal thickness measurement,A ultrasound pachymetry shows some limitations withy the increase of examination comfort and speed.New noncontact devices to measure corneal thickness have been developed,but measurement deviation must be noticed.