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阿尔茨海默病发病机制中相关因素的研究进展 被引量:16

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摘要 阿尔茨海默病(Alzheimer’sdisease,AD)是一种神经退行性疾病,AD的病理改变主要为皮质弥漫性萎缩,沟回增宽,脑室扩大,神经元大量减少,并可见老年斑(SP)、神经原纤维缠结(NFT)等。通常认为SP和NFT是AD的病理学标志,
作者 章正 罗焕敏
出处 《中华老年医学杂志》 CAS CSCD 北大核心 2011年第3期256-259,共4页 Chinese Journal of Geriatrics
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  • 1Armstrong RA. The molecular biology of senile plaques and neurofibrillary tangles in Alzheimer' s disease. Folia Neuropathol, 2009,47 : 289-299.
  • 2Murphy MP, LeVine H 3rd. Alzheimer's disease and the amyloid-beta peptide. J Alzheimers Dis, 2010, 19 : 311-323.
  • 3Kumar-Singh S, Theuns J, Van Broeck B, et al. Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Abeta42 and decreased Abeta40. Hum Mutat,2006, 27:686-695.
  • 4Rebeck GW, Hoe HS,Moussa CE.[beta]-Amyloidl -42 gene transfer model exhibits intraneuronal amyloid, gliosis, tau phosphorylation, and neuronal loss. J Biol Chem,2010,285:7440-7446.
  • 5Rankin CA, Sun Q, Gamblin TC. Tau phosphorylation by GSK-3beta promotes tangle-like filament morphology. Mol Neurodegener, 2007, 2 :12.
  • 6Tanemura K, Chui DH, Fukuda T, et al. Formation of tau inclusions in knock-in mice with familial Alzheimer disease (FAD) mutation of presenilin 1 (PS1). J Biol Chem,2006,281:5037-5041.
  • 7Arispe N, Diaz JC,Simakova O. Abeta ion channels. Prospects for treating Alzheimer's disease with Abeta channel blockers. Biochim Biophys Acta, 2007,1768 : 1952-1965.
  • 8Metcalfe MJ, Figueiredo-Pereira ME. Relationship between tau pathology and neuroinflammation in Alzheimer's disease. Mt Sinai J Med, 77 : 50-58.
  • 9Yu CE, Seltman H, Peskind ER, et al. Comprehensive analysis of ApoE and selected proximate markers for late-onset Alzheimerf s disease: Patterns of linkage disequilibrium and disease/marker association. Genomics, 2007, 89: 655-665.
  • 10Martins IJ, Berger T,Sharman MJ,et al. Cholesterol metabolism and transport in the pathogenesis of Alzheimer' s disease. J Neurochem, 2009, 111: 1275-1308.

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