摘要
通过添加OCT4、SOX2等转录因子,体外诱导细胞重编程获得诱导多能干细胞是近年干细胞领域的一大突破。OCT4、SOX2和NANOG等转录因子在启动细胞重编程、维持诱导多能干细胞多能性和决定其是否走向分化方面起了关键作用。对这些转录因子作用机制的了解,有助于细胞重编程分子机制的进一步阐明。
It has made great breakthrough in the filed of stem cell study recently that people are able to induce cell reprogramming to gain induced pluripotent stem（iPS） cell in vitro via adding transcription factors,such as OCT4 and SOX2.Transcription factors（OCT4,SOX2 and NANOG etc.） play an important role in starting the cell reprogramming,maintaining the pluripotency of iPS cells and deciding whether it differentiates.Researching the mechanism of action of these transcription factors is beneficial to the further explanation of the molecular mechanism of the cell reprogramming.
出处
《基础医学与临床》
CSCD
北大核心
2011年第4期458-462,共5页
Basic and Clinical Medicine
基金
第三军医大学创新基金(2007XG42)
