摘要
Grb7蛋白是Grb7蛋白家族的成员之一,该蛋白有3种结构区域:N末端富含脯氨酸,中间结构域与线虫(Caenorhabditis elegans)的MIG-10蛋白有着很高的同源性,C末端为SH2结构域。Grb7通过3种结构域尤其是SH2结构域,参与细胞各种信号传导途径。研究其不同结构域在肿瘤细胞中所发挥的作用,将对Grb7高表达的肿瘤治疗产生重要影响。
Growth factor receptor-bound 7（Grb7）,a member of Grb7 protein family,has three distinct functional regions： a lot of proline amino acids exist in its N terminal,and the mesial district has such similar amino acids sequence as that of MIG-10 protein from Caenorhabditis elegans,and a SH2 domain in its C terminal.With these different domain,Grb7 protein plays distinct roles in cellular signaling pathway.And if we know more about the biological function acted by different domains of Grb7 protein,people may be benefited from treatment of patients with high expression of Grb7 protein.
出处
《基础医学与临床》
CSCD
北大核心
2011年第4期467-470,共4页
Basic and Clinical Medicine
