hOGG1基因Ser326Cys多态性与肺癌易感性的meta分析研究

Meta Analysis of Association between Ser326Cys Polymorphism of hOGG1 Gene and Risk of Lung Cancer

背景与目的就全世界范围内而言,肺癌是一种常见疾病。人8-羟基鸟嘌呤糖苷酶(human8-hydrox-yguanine glycosylase,hOGG1)是一种DNA修复酶,它能特异切除8-羟基鸟嘌呤(8-dihydro-8-oxoguanine,8-OH-G),对损伤的DNA进行修复。hOGG1Ser326Cys基因多态性与癌症易感性的关系一直是研究的热点,而该多态性与肺癌易感性的关系尚存在争议。本研究采用meta分析旨在更好地探讨hOGG1Ser326Cys多态性与肺癌易感性之间的关系。方法使用MEDLINE数据库检索2010年11月以前的相关文献,按照纳入标准,全面搜索含有研究hOGG1Ser326Cys多态性与肺癌易感性相关的信息。由至少两位评论员做独立文献筛选和资料提取,并交叉审核。使用STATA10.1软件进行统计分析。结果根据检索条件,共有22篇文献(包括8,575例肺癌患者和9,484名正常对照个体)被纳入当前的meta分析。分析结果表明22项研究的结果存在明显异质性,当排除不符合Hard-Weinberg平衡定律的两篇文献后,其余的文献呈现出较好的同质性。与hOGG1Ser326相比,Cys326基因型明显增加了肺癌发病风险(OR=1.24,95%CI:1.10-1.39,P<0.001)。这种正相关在亚洲人群和医院来源的样本中尤为明显(OR=1.28,95%CI:1.11-1.49;OR=1.26,95%CI:1.09-1.46)。结论 hOGG1Ser326Cys多态性与肺癌易感性之间存在明显相关性,Cys326基因型能明显增加肺癌发病风险。

Background and objective Human 8-hydroxyguanine glycosylase（hOGG1） is one of the DNA repair genes,which can repair damaged DNA by speci cally excising 8-dihydro-8-oxoguanine（8-OH-G） .A considerable number of studies investigating hOGG1 Ser326Cys polymorphism were in relation to various cancers.However,the association of hOGG1 Ser326Cys polymorphism with risk of lung cancer is inconsistency.e aim of this study is to assess the association of hOGG1 Ser326Cys polymorphism with risk of lung cancer by conducting a meta-analysis.Methods To identify all studies that are quali ed for meta-analysis,we conducted a computerized literature search of MEDLINE database（before November,2010） . Two investigators independently extracted the data and reached a consensus on all items.Results According to our search lim-its,twenty-two case-control studies,including 8,575 lung cancer cases and 9,484 controls,were selected for meta-analysis.Sig-ni cant heterogeneity was found among those twenty-two case-control studies,when excluding two studies that were not ac-corded with Hard-Weinberg Equilibrium,the remains performed well homogeneity.Compared with Ser326 genotype,Cys326 genotype can signi cantly increase risk of lung cancer（OR=1.24,95%CI：1.10-1.39,P0.001） ,especially in Asian ethnic popu-lation and hospital population（OR=1.28,95%CI：1.11-1.49;OR=1.26,95%CI：1.09-1.46） .Conclusion e present study indicates that the hOGG1 Ser326Cys polymorphism is associated with risk of lung cancer,Cys326 genotype can signi cantly increase risk of lung cancer.