脑微出血与华法林相关性脑出血的相关性

Correlation between cerebral microbleeds and warfarin-related intracerebral hemonhage

目的探讨脑微出血与华法林相关性脑出血之间是否存在相关性。方法选择34例在院外服用华法林后发生脑出血的患者作为脑出血组，54例同一时期服用华法林但未发生脑出血的患者作为对照组，比较两组间的一般资料、脑血管危险因素、凝血功能等实验室检查以及脑微出血的影像学检查情况。结果脑出血组脑微出血检出率（82．4％对22．2％，P〈0．001）和病灶数量（10．40±25．6对0．60±1．09，P〈0．001）均显著高于和多于对照组。多变量log＆tic回归分析显示，国际标准化比率过高（OR4．241，95％CI1．421～12．198；P=0．012）和脑微出血（OR79．827，95％C16．113～368．13；P=0．001）是华法林相关性脑出血的独立危险因素。结论脑做出血是华法林相关性脑出血的独立危险因素。

Objeclive To investigate whether there is a correlation between cerebral microbleeds and warfarin-related intracerebral hemorrhage （ICH）. Methods Thirty-four patients developed ICH after taking warfarin outside the hospital were used as microbleed group, and 54 patients without developing ICH after taking warfarin at the same period were used as control group. The general information, cerebrovascular risk factors, and laboratory tests, such as coagulation function and imaging findings of cerebral microbleeds between the two groups were compared. Results The detection rate of cerebral microbleeds （82.4% vs. 22.2%, P〈0. 001） the number of lesions （10. 40 ± 25.60 v.s. 0.60 ± 1.09, P 〈 0. 001 ） in the microbleed group were significantly higher and more than those in the control group. Multivariate logistic regression analysis showed that the international normalized ratio was too high （OR 4. 241, 95% CI 1. 421-12. 198; P =0. 012）, and cerebral microbleeds （OR 79. 827, 95% CI 6. 113- 368.13; P =0.001 ） were the independent risk factor for warfarin-related ICH. Conclusions Cerebral microbleeds were the independent risk factors for warfarin-related ICH.