非小细胞肺癌患者血清血管内皮生长因子C的水平及临床意义

Expression of VEGF-C in the serum of NSCLC patients and its clinicopathologic significance

目的:探讨非小细胞肺癌患者(NSCLC)血清血管内皮生长因子C(VEGF-C)表达水平及其与临床病理特征之间的关系。方法:采集20例健康体检者、30例肺炎患者及60例NSCLC患者血清,用ELISA方法检测VEGF-C表达水平。结果:NSCLC患者血清VEGF-C水平远高于正常健康人群组(P<0.01)和肺炎患者(P<0.05);有淋巴结转移的NSCLC患者血清VEGF-C水平明显高于无淋巴结转移者(P<0.05);Ⅲ、Ⅳ期NSCLC患者血清VEGF-C水平明显远高于Ⅰ、Ⅱ期患者(P<0.01);NSCLC患者血清VEGF-C水平与患者生存时间呈负相关(P<0.05)。结论:NSCLC患者血清VEGF-C的表达与病情进展密切相关,并可作为一种有用的预后指标。

Objective：Evaluate the relationship between the level of serum vascular endothelial growth factor-C（VEGF-C）and the clinical-pathological features in patients with non-small-cell-lung-cancer（NSCLC）.Method：Serum expression level of VEGF-C in 20 healthy controls,30 cases of pneumonia patients,and 60 cases of NSCLC patients were detected by ELISA.The relationship between VEGF-C expression level and the clinical features was analyzed.Results：Serum expression level of VEGF-C in the NSCLC patients group was significant higher than that in the healthy control group（P0.01）or the pneumonia control group（P0.05）.NSCLC patients with lymph node metastasis had a higher VEGF-C expression level than that without lymph node metastasis（P0.05）.NSCLC patients in stage III and stage IV had a higher VEGF-C expression level than that in stage I and stage II（P0.01）.The expression level of VEGF-C has a negative correlation with the survival time of NSCLC patients（P0.05）.Conclusion：Serum VEGF-C levels of NSCLC patients was correlated with the progression and survival time and it can serve as a prognostic marker of NSCLC patients.