Survivin和bFGF在子宫内膜样腺癌中的表达及其意义

The expression of Survivin and bFGF in endometrioid carcinoma and clinical significance

目的检测凋亡抑制基因Survivin、碱性成纤维细胞生长因子(basic fibroblast growth factor,bFGF)在子宫内膜样腺癌组织中的表达水平并进行相关性分析,以探讨二者与子宫内膜样腺癌的发生、发展的关系。方法用免疫组化S-P方法对子宫内膜样腺癌50例、非典型增生子宫内膜40例、正常子宫内膜35例进行Survivin和bFGF的检测。结果 Survivin和bFGF的阳性率在子宫内膜癌组织中远高于非典型增生和正常子宫内膜,差异有显著性(P<0.05),其表达率与淋巴结转移有关(P<0.05)。Survivin的阳性率则随着病理分级的升高而增加(P<0.05),bFGF的阳性率随着病理分级的升高而升高(P<0.05)。结论 Survivin和bFGF表达与子宫内膜样腺癌的发生、发展密切相关,为子宫内膜样腺癌的发展及预后判断提供了一种新的参考指标。

Objective：To investigate the expressive level of Survivin and basic fibroblast growth factor（bFGF） in endometrioid carcinoma and explore the correlation between the expression and to elucidate the role of Survivin and bFGF in tumor occurrence and development of endometrioid carcinoma.Methods： The expression of Survivin and bFGF in 50 cases of endometrioid carcinoma,40 cases atypical hyperplasia endometrium and 35 cases normal endometrium was detected immunohistochemically by S-P method.Results： The positive rate of Survivin and bFGF was higher in endometrioid carcinoma group than that in endometrial atypical hyperplasia and normal endometrium（P0.05,respectively）.The expression of Survivin and bFGF in the group with Lymph node metastasis was also significantly different from that in the group without Lymph node metastasis（P0.05）.The expression of Survivin and bFGF in G3 group of endometrioid carcinoma was also significantly different from G1-G2 group（P0.05）.Conclusion： The results indicate that both Survivin and bFGF may participate in the process of occurrance and progression in endometrioid carcinoma.Combined detection of Survivin and bFGF may be a new parameter in evaluating progression and prognosis of endometrioid carcinoma.