柿叶黄酮及其联合卡托普利对肾性高血压大鼠血压的影响

Effects of persimm on leaf flavonoids and combined with captopril on blood pressure in renovascular hypertensive rats

目的观察柿叶黄酮及其联合卡托普利对肾性高血压大鼠血压的影响。方法建立两肾一夹(2K1C)肾性高血压大鼠模型。随机分为模型组、柿叶黄酮(PLF)组、卡托普利(CAP)组、PLF+CAP组;每天给药1次,灌胃给药4周,假手术组给予等容量生理盐水;后停药1周。定期以无创尾套法测定大鼠尾动脉收缩压(SBP)和心率(HR)。结果与模型组相比,给药3天后PLF+CAP组表现显著降压作用伴有心率减慢(P<0.05),给药3周后PLF组出现降压作用伴有心率减慢(P<0.05),停药7天后PLF+CAP组血压回升幅度最小(P<0.05)。结论柿叶黄酮及其联合卡托普利对肾性高血压大鼠具有降压作用。

Objective：To observe the effect of persimm on leaf flavonoids（PLF） and combined with captopril（CAP） on blood pressure in renovascular hypertensive rats.Methods： Two-kidney one clip（2K1C）renal hypertensive rats were randomly divided into model group,PLF group,CAP group,PLF＋CAPgroup,in which oral administration was given once daily for 4weeks but sham operation group received normal saline.Withdrawal was in one week.Systolic blood pressure（SBP） and the heart rate（HR） of RHRs were measured by tail cuffmethod regularly.Results：Compared with model group,3 days after administration of P-C group showed a significant antihypertensive effect associated with heart rate（P0.05）.1 week after discontinuation P-C group had the smallest rise in blood pressure（P0.05）.Conclusion：The persimmon leaf flavonoids combined with captopril on the RHR has a satisfactory hypotensive effect.