“试管婴儿”技术30年——回顾和展望

30 years of "test-tube baby" technology: retrospect and prospect

1978年第一例试管婴儿诞生以及随后近30多年来该领域不断取得的突破性进展,促进了以体外受精为基础的辅助生殖技术在临床的广泛应用,并取得了很好的疗效。本文将系统回顾近30多年来辅助生殖技术在临床和实验室两方面建立的包括:控制性超排卵、序贯培养、精子胞浆内注射以及植入前遗传学诊断和筛查等主要技术突破,并对医源性多胎、新技术的安全性等目前存在的主要问题及可能的解决方案进行探讨。

Since the birth of the first ＂test-tube baby＂in 1978,numerous achievements have been made on assisted reproductive technology（ART） in recent 30 years,which promotes its broad and successful clinical application.Here,we systematically review the important advancements in in vitro fertilization treatment,including controlled ovarian hyperstimulation,sequential embryo culture,intracytoplasmic sperm injection and preimplantation genetic diagnosis and screening,etc.We will also discuss the major challenges nowadays in ART,including multiple gestation,safety issue of newly developed technology.