泌尿生殖道支原体抗菌药物敏感性检测

Mycoplasma Susceptibility to Antibiotics

目的检测我院门诊泌尿生殖道支原体感染情况及对抗生素的药敏分析。方法采用微量肉汤稀释法对638例泌尿生殖道感染者进行解脲支原体(Uu)和人型支原体(Mh)的检测,并对确诊的364例非淋菌性尿道炎/宫颈炎患者的解脲支原体(Uu)和人型支原体(Mh)进行12种抗生素的药敏试验。结果检出支原体427例,阳性率66.92%,女性患者(81.12%)明显高于男性患者(34.20%),且Uu感染(45.92%)明显高于Mh感染(11.13%)和Uu﹢Mh混合感染(9.87%)。药敏试验显示:Uu对ROX(42.66%)、AZI(41.30%)、CIP(66.21%)、OFL(45.05%)、ERY(89.08%)耐药,而对JOS(1.02%)、DOX(11.26%)、MIN(11.26%)较为敏感。Mh对ROX(84.51%)、AZI(91.55%)、CIP(73.24%)、SPA(40.85%)、OFL(60.56%)、CLA(73.24%)、LEV(43.66%)、ERY(97.18%)耐药,而对JOS(1.41%)、DOX(7.04%)、MIN(7.04%)比较敏感。结论支原体培养加药敏试验结果,在指导临床上治疗非淋菌性尿道炎/宫颈炎的合理用药及提高临床疗效方面十分重要。

Objective To determine mycoplasma infection and drug susceptibility to antibiotics in our hospital.Methods 638 patientss of genitourinary infection of Ureaplasma urealyticum（Uu） and Mycoplasma hominis（Mh） were detected with broth dilution medium.12 antibiotics sensitivity test were made in 364 patients diagnosed with non-gonococcal urethritis / cervicitis Ureaplasma urealyticum（Uu） and Mycoplasma hominis（Mh）.Results 427 cases of patients with mycoplasma,the positive rate of 66.92%,female patients（81.12%） than male patients（34.20%）,The Uu infection（45.92%） was significantly higher than that of Mh infection（11.13%） and mixed infection（Uu ＋ Mh）.IT was showed that the Uu was not sensitive for ROX（42.66%）and AZI（41.30%）,and CIP（66.21%）,and OFL（45.05%） and ERY（89.08）,and sensitive for JOS（1.02%） and DOX（11.26%） and（11.26%）.IT was showed that the Mh was not sensitive for ROX（84.51%）and AZI（91.55%）and CIP（73.24%）and SPA（40.85%）and OFL（60.56%）and CLA（73.24%）and LEV（43.66%）and ERY（97.18%）,and sensitive for JOS（1.41%）and DOX（7.04%）and MIN（7.04%）.Conclusions It was very important for the results of susceptibility testing of mycoplasma in guiding the clinical treatment of non-gonococcal urethritis / cervicitis and rational use of drugs and improving clinical efficacy.