摘要
Objective: A novel PVA-CaAlg composite material by polyvinyl alcohol (PVA) and sodium alginate (SA) was fabricated to investigate the feasibility serving as a scaffold for tissue engineering and to find out the most ideal proportion according to their properties. Methods: Film, graininess and sponge scaffolds of PVA-CaAlg were fabricated by three different methods. Water content and swelling ratio were tested. SEM was used to observe the configuration of the cross section. Results: Different proportional scaffolds could be obtained with different PVA molecular weight, alcoholysis degree and different SA dosages. The water content of different scaffolds ranged from 48% to 93% and showed different inner configuration with swelling ratio between 120% and 470%. SEM proved that different composite materials had different porous structures. Conclusion: A scaffold for tissue engineering with high water content and proper swelling ratio can be fabricated using PVA and SA. The porous structure shows potential in tissue engineering and cell culture.
Objective： A novel PVA-CaAlg composite material by polyvinyl alcohol （PVA） and sodium alginate （SA） was fabricated to investigate the feasibility serving as a scaffold for tissue engineering and to find out the most ideal proportion according to their properties. Methods： Film, graininess and sponge scaffolds of PVA-CaAlg were fabricated by three different methods. Water content and swelling ratio were tested. SEM was used to observe the configuration of the cross section. Results： Different proportional scaffolds could be obtained with different PVA molecular weight, alcoholysis degree and different SA dosages. The water content of different scaffolds ranged from 48% to 93% and showed different inner configuration with swelling ratio between 120% and 470%. SEM proved that different composite materials had different porous structures, Conclusion： A scaffold for tissue engineering with high water content and proper swelling ratio can be fabricated using PVA and sA. The porous structure shows potential in tissue engineering and cell culture.
