多重耐药铜绿假单胞菌耐药状况分析

Analysis on multi-drug resistance on Pseudomonsa aeruginosa

目的了解医院铜绿假单胞菌对常用抗菌药物的耐药谱动态变化,为临床合理选用抗菌药物提供依据。方法应用回顾性调查方法,对本院从2005年1月至2009年6月间临床样本分离的铜绿假单胞菌的药敏试验进行对比统计分析。结果所分离出的1125株铜绿假单胞菌对常用抗菌药物的耐药率总体呈上升趋势。耐药率最低的是美罗培南(33%)。铜绿假单胞菌对常见抗菌药物的耐药性均有显著性变化。结论本地区铜绿假单胞菌耐药率有显著性变化,多重耐药现象严重,动态监测其耐药谱变化是防止铜绿假单胞菌的感染率攀升的重要措施。

Objective To understand the dynamic changes of antibiotic resistance spectrum of Pseudomonsa aeruginosa in hospital so as to provide evidences for the utilization of antibiotics in clinical reasonably. Methods Pseudomonsa aeruginosa were isolated from clinical samples and their resistances to antibiotics in the hospital from Jan 2005 to June 2009 were analyzed and studied retrospectively. Results A total of I 125 Pseudomonsa aeruginosa were isolated, and there was an elevated tendency for the resistance to common antibiotics during the past years. Meropenem was the drug with the lowest resistance rate （33%）. The resistance rate to common antibiotics had changed remarkably. Conclusion Pseudomonsa aeruginosa has an elevated tendency on antibiotic resistance rate, the phenomenon of nmhi-drug resistance was serious. It was an important measure to prevent the elevation for the infection of Pseudomonsa aeruginosa by dynamic monitoring the change of the antibiotic resistance spectrum.