延安地区中枢神经系统疾病患者弓形虫感染抽样调查

Sample survey on toxoplasma infection among patients with central nervous system diseases in Yan'An

目的了解延安地区中枢神经系统疾病患者TOX感染情况。方法应用ELISA法对180例不明原因神经系统疾病患者和135例健康体检者进行ATAb检测。结果病例组ATAb的阳性率为28.89%(52/180),对照组为9.63%(13/135)。不同类型疾病患者ATAb阳性率分别为:脑型28.05%(23/82)、癫痫型44.44%(4/19)、精神病型32.14%(9/28)、神经衰弱型26.23%(16/61)。有宠物接触史者ATAb阳性率为47.62%(30/63),无接触史者ATAb阳性率为18.80%(22/117)。结论病例组ATAb阳性率明显高于对照组,两组间差异有极显著性(P<0.01)。不同类型疾病患者ATAb阳性率无显著性差异(P>0.05)。有宠物接触史者ATAb阳性率明显高于无接触史者,两者间差异有极显著性(P<0.01),说明TOX感染与接触宠物有关。

Objective To understand the toxoplasma infection among patients with central nervous system diseases in yan＇an. Methods The ATAb were detected in 180 cases with diseases of nervous system in vague pathogenesis and 135 health people by ELISA. Results The positive rate of ATAb in the case group and the control group was 28.89% （52/180） and 9.63% （13/135）, respectively. The positive rate of ATAb was different in different types of diseases. The positive rate in encephalopathy, epilepsyin, mental disorder and neurasthenia was 28.05% （23/82）, 44. 44% （4/9）, 32. 14% （9/28） and 26. 23% （ 16/61 ）, respectively. The positive rate was 47.62% （30/63） in the case with the history of exposure to pets, and 18.80% （22/117 ） in the case with non-contact to pets. Conclusions The positive rate of ATAb in the case group was significantly higher than that in health population. There was no significant difference among the different types of nervous system diseases. The positive rate of ATAb in the case with the history of exposure to pets was significantly higher than that in the case with non-contact to pets. Therefore, the infection of toxoplasma was relevant with pets contacting.