直肠癌镶嵌淋巴管的表达及其临床意义

Expression of Mosaic lymphatic in human rectal carcinoma and its clinical significance

目的探讨镶嵌淋巴管（ML）的表达及其临床意义。方法通过免疫组织化学法将48例直肠癌组织切片染色，观察直肠癌组织中的镶嵌淋巴管形态，并进行其与浸润深度、淋巴结转移及远处转移的相关分析。结果46例直肠癌患者中有17例ML阳性，并且ML与直肠癌浸润深度无明显相关（r=-0．133，P〉0．05），与淋巴结转移（r=0．474）、远处转移（r=0．417）呈正相关（P〈0．01）。结论直肠癌淋巴管嵌合体的表达与直肠癌浸润深度、淋巴结转移及远处转移呈正相关，它可提示病情的发展及预后。

Objective To study the expression of mosaic lymphatic （ML） in human rectal carci- noma and its clinical significance. Methods Forty-eight specimens of rectal carcinoma were stained by immunohistochemical method. The patterns of mosaic lymphatic in rectal carcinoma were observed, and their correlation with invasion, lymph node metastasis and distant metastasis of rectal carcinoma was ana- lyzed. Results ML was found in 17 of the 46 specimens, and there was no significant correlation between ML and invasion depth of rectal carcinoma. But ML was associated with existence of lymph node metastasis （ r = 0. 474, P 〈 0. 01 ） and distant metastasis （ r = 0. 417, P 〈 0. 01 ） positively. Conclusion There was a positive correlation between the expression of LM with invasion depth, lymph node metastasis and distant metastasis.