偶合反应流动注射化学发光法测定扑热息痛

Flow injection chemiluminescence determination of paracetamol with chromium(VI)-H_20_2-luminol system

基于扑热息痛还原铬(Ⅵ)和铬(Ⅲ)催化鲁米诺-过氧化氢的化学发光,建立了氧化还原偶合反应流动注射化学发光法测定扑热息痛的新方法。方法线性范围为4.0×10-9～4.0×10-5mol/L,检出限为1.0×10-9mol/L。对4.0×10-7mol/L扑热息痛平行测定8次,其标准偏差为2.7%。已将该方法用于片剂中扑热息痛含量测定。

As chromium（Ⅵ） can be reduced by paracetamol to chromium（Ⅲ） which enhance the CL intensity of luminol-H2O2 system,a new chemiluminescent method for the determination of paracetamol was developed.The relative CL intensity was 1inearly related to the concentration of paracetamol in the range of 4.0×10-9～4.0×10-5mol/L with a detection limit of 1.0×10-9 mol/L.The relative standard deviation（n=8） for 4.0×10-7 mol/L paracetamol was 2.7%.The method has been applied to the determination of paracetamol in the tablets.