敦煌大宝胶囊对衰老大鼠脑组织NO/NOS表达水平及钙平衡的影响

Effect of DHDB on NO and NOS Expression Levels and Calcium Homeostasis in Brain Tissue of Aging Rats

目的:探讨敦煌大宝胶囊对衰老模型大鼠脑组织NO/NOS表达水平及钙平衡的影响。方法:采用D-半乳糖建立大鼠衰老模型,测定各组大鼠脑组织内NO/NOS表达水平、Ca2+-ATPase活性以及Ca2+含量。结果:模型组大鼠脑组织内NO/NOS水平、Ca2+含量显著升高(P<0.05),Ca2+-ATPase活性显著降低(P<0.05);经敦煌大宝胶囊治疗后,大鼠脑组织内NO/NOS水平、Ca2+含量显著降低(P<0.05),Ca2+-ATPase活性显著升高(P<0.05)。结论:敦煌大宝胶囊具有调节衰老大鼠脑组织NO/NOS表达水平以及钙平衡的作用。

Objective：To explore the effect of DHDB on NO /NOS expression levels and calcium homeostasis in brain tissue of aging model rats.Methods：The subacutely aging model rats were made by injecting D-gal into abdominal cavity continually,and NO、NOS、Ca2 ＋-ATPase and Ca2 ＋ levels in brain tissue were evaluated.Results：The NO,NOS and Ca2 ＋ levels in model group were downregulated（P 0.05）,Ca2 ＋-ATPase levels in that was increased significantly（P 0.05）.After treated with DHDB,NO,NOS and Ca2 ＋ levels were upregulated（P 0.05）,Ca2 ＋ levels was reduced significantly（P 0.05）.Conclusions：The results demonstrated that DHDB can regulate metabolism of NO,NOS and Calcium Homeostasis in brain tissue.