摘要
报道了在氢氧化钙存在下,氯苄经八羰基二钴催化双羰基化合成苯基丙酮酸的方法。主要研究了八羰基二钴对不同的卤代芳烃催化双羰基化的活性,以及温度、压力、溶剂极性对单、双羰基化反应的影响,通过选择适当的反应条件,获得了氯苄经催化双羰基化合成苯基丙酮酸最高产率达92.2%的最佳条件。产品经元素分析、熔点测定及质谱、紫外、核磁、红外检测均符合苯基丙酮酸结构。并对该反应的催化机理进行了讨论。
The synthesis of phenylpyruvic acid from benzyl chloride via dicobal-toctacarbonyl catalyzed double carbonylation in the presence of CaOH was reported in the paper. The effects of dicobalt-octacarbonyl on the activity of various halogen aromatic hydrocarbons catalyzed double carbonylation and the effects of temperature, pressure, and solvent polarity on single or double carbonylation were mainly discussed, An optimum condition under which the maximum yield of phenylpyruvic acid (92.2%) synthesized by catalyzed double carbonylation of benzyl chloride was achieved through the selection of proper reation conditions. The products were identified by means of. UV, MS, NMR, IR, element analysis and melting point.
出处
《天然气化工—C1化学与化工》
CAS
CSCD
北大核心
1990年第2期20-24,共5页
Natural Gas Chemical Industry
基金
国家自然科学基金资助课题
