新生儿败血症时外周血CD4^+CD25^+CD127^(low/-)调节性T细胞的变化及其临床意义

The Change and Clinical Significance of Circulating CD4^+CD25^+CD127^(low/-)Regulatory T Cells in Neonatal Sepsis

目的探讨新生儿败血症时外周血CD4+CD25+CD127low/-调节性T细胞(Treg细胞)的水平及其意义。方法用流式细胞仪检测26名正常足月新生儿(正常足月儿组)、14例单纯早产儿(单纯早产儿组)及21例新生儿败血症患儿(败血症组)外周血中CD4+CD25+CD127low/-Treg细胞的水平。结果正常足月儿组与单纯早产儿组差异无统计学意义(P>0.05);败血症组与正常足月儿组、单纯早产儿组比较均显著升高(均P<0.01)。结论外周血中Treg细胞的相对增加可能在新生儿败血症发生后淋巴细胞应答无能及免疫抑制中发挥作用。

Objective To explore the level and significance of circulating CD4 ＋CD25 ＋CD127low/-regulatory T cells（Treg） in neonatal patients with sepsis.Methods Using flow cytometric measurement to assess the level of circulating CD4 ＋CD25 ＋CD127low/-regulatory T cells in 26 normal full-term infants（normal full-term group）,14 simply premature infants（simply premature group） and 21 neonates with sepsis（septic group）.Results There was no significant difference between normal full-term group and simply premature group（P0.05）.However,there was significant statistic difference in septic group versus normal full-term group and simply premature group（P0.01）.Conclusion The relative increase in circulating Treg might play a role in lymphocyte anergy and immunosuppression described after sepsis.