期刊文献+

艾塞那肽治疗2型糖尿病的疗效 被引量:3

下载PDF
导出
摘要 艾塞那肽是一种新的人工合成的胰高血糖素样肽-1(GLP-1)类似物,临床试验证实其可持续有效地控制2型糖尿病(T2DM)患者的血糖,减轻体重,并能改善胰岛B细胞功能,且发生低血糖的风险低,是T2DM患者治疗的新选择。本研究对服最大耐受剂量二甲双胍或(和)磺脲类药后血糖仍控制不佳的T2DM患者加用艾塞那肽治疗,并评价其有效性和安全性。
出处 《上海医学》 CAS CSCD 北大核心 2010年第12期1141-1142,共2页 Shanghai Medical Journal
  • 相关文献

参考文献1

二级参考文献25

  • 1Dov A, Abramovitch E, Warwar N, et al. Diminished phospho-diesterase-SB potentiates biphasic insulin response to glucose. Endocrinology, 2008,149:741-748.
  • 2Yaekura K, Julyan R, Wicksteed BL, et al. Insulin secretory deficiency and glucose intolerance in Rab3A null mice. J Biol Chem, 2003,278,9715-9721.
  • 3Doyte M, Egan JM. Pharmacological agents that directly modulate insulin secretion. Pharmacol Rev, 2003,55:105-131.
  • 4Park H, Dong X, Fisher TL, et al. Exendin-4 uses Irs 2 signaling to mediate pancreatic β cell growth and function. J Biol Chem, 2006, 281:1159-1168.
  • 5Knoch KP, Meisteffeld R, Kersting S, et al. cAMP-dependent phosphorylation of PTB1 promotes the expression of insulin secretory granule proteins in β cells. Cell Metab, 2006,3:123-134.
  • 6Buteau J, Spatz ML, Accili D. Transcription factor FoxO1 mediates glucagon-like peptide-1 effects on pancreatic β-cell mass. Diabetes, 2006,55 : 1190-1196.
  • 7De Heer J, Hoist JJ. Sulfonylurea compounds uncouple the glucose dependence of the insulinotropic effect of glucagon-like peptide 1. Diabetes, 2007,56:438-443.
  • 8MacDonald PE, Wheeler MB. Vohage-dependent K^+ channels in pancreatic β cells: role, regulation and potential as therapeutic targets. Diabetologia, 2003,46 : 1046-1062.
  • 9Dyachok O, Isakov Y, Sagetorp J, et al. Oscillations of cyclic AMP in hormone-stimulated insulin-secreting β-cells. Nature, 2006,439 : 349- 352.
  • 10Kang G, Chepumy OG, Rindler MJ, et al. A cAMP and Ca^2+ coincidence detector in support of Ca^2+ -induced Ca^2+ release in mouse pancreatic β cells. J Physiol, 2005,566 : 173-188.

共引文献37

同被引文献23

  • 1谢爱霞,吴胜利,李农,黄雪芳,高晖,高丽霞,王海丽,张红霞.肥胖与糖尿病、高血压病的相关性探讨[J].中国糖尿病杂志,2007,15(9):556-557. 被引量:24
  • 2Edavalath M,Stephens JW.Liraglutide in the treatment of type 2 diabetes mellitus:clinical utility and patient perspectives[J].Patient Prefer Adherence,2010(4):61-68.
  • 3Zinman B,Gerich J,Buse JB,et al.Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met + TZD)[J].Diabetes Care,2009,32 (7):1224-1230.
  • 4Garber A,Henry R,Ratner R,et al.Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono):a randomised,52-week,phase Ⅲ,double-blind,parallel-treatment trial[J].Lancet,2009,373(9662):473-481.
  • 5Salehi M,Aulinger BA,D'Alessio DA.Targeting beta-cell mass in type 2 diabetes:promise and limitations of new drugs based on incretins[J].Endocr Rev,2008,29 (3):367-379.
  • 6Nauck M,Frid A,Hermansen K,et al.Efficacy and safety comparison of liraglutide,glimepiride,and placebo,all in combination with metformin,in type 2 diabetes:the LEAD (liraglutide effect and action in diabetes)-2 study[J].Diabetes Care,2009,32(1):84-90.
  • 7Cariou B.Harnessing the incretin system beyond glucose control:potential cardiovascular benefits of GLP-1 receptor agonists in type 2 diabetes[J].Diabetes Metab,2012,38(4):298-308.
  • 8Russell-Jones D.The safety and tolerability of GLP-1 receptor agonists in the treatment of type-2 diabetes[J].Int J Clin Pract,2010,64(10):1402-1414.
  • 9Lind M.Glucagon-like peptide-1(GLP-1)analogue combined with isulin reduces HbA了c and weight with low risk of hypoglycemia and high treatment satisfaction[J].Primary Care Diabetes,2012,6(1):41-47.
  • 10周岩,姬秋和.多重获益——利拉鲁肽联合口服药的临床研究[J].药品评价,2010,7(11):22-23. 被引量:5

引证文献3

二级引证文献15

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部