大骨节病发病机制与防治研究的新进展及其展望

New progression and prospect on pathogenesis and control of Kashin-Beck disease

大骨节病是一种地方性变形性骨关节病,至今原因未明,且尚无有效治疗措施。本文依据国内外相关研究,结合作者及其研究团队的研究工作,从病因学评价、家庭聚集性及其影响因素、软骨损伤的分子生物学和防治研究方面综述了近年来的研究新进展,认识到深入在基因和蛋白组学水平上筛选大骨节病软骨早期损伤的分子生物学标志研究,建立早期诊断和疾病监测大骨节病的分子生物学技术,是未来提高我国大骨节病防治水平的重要目标之一。

Kashin-Beck disease (KBD) is an endemic and deforming osteochondropathy, and its pathogenesis remains unclear with no effective treatment measures up to now. This article summarized the new progression and problems from the etiological evaluation, factors related to the family aggregation, molecular biology on cartilage damage and prevention and cure, and an overview of progress in a number of new researches by reviewing literatures published from both abroad and China. Integrating with the research works of self and his team colleagues, the author suggested that one of the important objectives in future are to establish the molecular biology techniques for early diagnosis and monitoring of KBD following the molecular biological markers screened in the early stage of cartilage damage with KBD thorough the gene and proteomic strategy to improve the prevention and cure level of KBD in China.