同种异体皮在皮肤软组织严重毁损性创面修复中的应用

Allogeneic skin in severe damage in skin and soft tissues

目的探讨同种异体皮覆盖急性毁损性创面,提高患者救治成功率及促进创面愈合的可行性。方法 回顾性分析56例急诊住院治疗皮肤软组织严重毁损性患者的临床病例,按治疗方法分组:急诊清创后同种异体皮覆盖创面,待二期修复创面的28例为治疗组;清创后一期皮瓣、植皮封闭创面的28例设为对照组,观察两组患者的救治成功率和创面封闭时间。结果 两组救治成功率分别为96.43%和78.57%,差异具有统计学意义(P<0.05);实验组创面治愈时间(16.17±1.87)d与实验组(21.71±3.95)d,差异具有统计学意义(P<0.01)。结论 皮肤软组织严重毁损性损伤急诊手术应以稳定患者全身情况为重点,创面使用同种异体皮覆盖待二期修复,可降低急诊手术的风险性,提高患者救治成功率,缩短治疗周期。

Objective To discuss the effect of covering allogeneic skin on severe damaged wound,accelerate wound＇s healing and increase success rate.MethodsWe selected 54 emergency patients who had severe damage in skin and soft tissues during May 2005 to May 2010.According to the different treatment,they were divided into two groups,28 cases using allogeneic skin cover as treatment group and 27 cases using first stage skin grafting as control group.The success rate and healing rate of this two treatments were obsenved.Results Success rate and healing rate of treatment group were better than the control group,having a satisfied appearance and function after second stage＇s repair.Conclusions Covering allogeneic skin on severe damaged skin and soft tissues can shorten emergency surgery＇s time and reduce its risk,improve the wound＇s healing rate. KeywordsAllogeneic skin;Severe wound;Wound healing