神奇口服液的制备及质量控制

Preparation and quality control of the Shenqi oral liquid

目的优选神奇口服液的制备工艺。方法采用正交设计法,考察提取时间、次数、加水量及提取温度等4个因素。以黄芪多糖含量为指标成分。结果通过温度调节控制神奇口服液的澄清工艺。最佳制备工艺:加药材5倍量水提取2次,每次25min。浓缩液加0.2%山梨酸,添加甜蜜素为矫味剂,以稀HCL调节pH值至5.0-6.0得到口服液。结论本制剂稳定。测定方法重复性好。

OBJECTIVE To optimize the preparation technology of the shenqi oral liquid.METHODS Orthogonal design was carried out for estimating 4 factors：extracting time,the times of extraction,volume of water for dilution and the extraction temperature in the shenqi oral liquid.Astragalus polyaccharin was chose as the indicator.RESULTS Optimization preparation design：temperature regulation was used in the shenqi oral liquid,it was extracted with 6 volumes of water to Radix Astragali liquid at the temperature 60℃ for 2 times（25min for each time）.CONCLUSION The preparation is stable with good repeatability of measurement.