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抗凋亡基因Survivin转录调节的研究进展 被引量：2

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摘要 Survivin基因作为目前所发现的最强的凋亡抑制基因,具有强大的抗凋亡和调控细胞周期作用,并异常高表达于大部分肿瘤组织,显示出与肿瘤发生、发展及预后密切相关。
作者 王伟 孙兴旺
机构地区 泸州医学院基础医学院
出处 《现代临床医学》 2011年第2期89-92,共4页 Journal of Modern Clinical Medicine
关键词 基因SURVIVIN 抗凋亡 转录调节 SURVIVIN基因 凋亡抑制基因 细胞周期 肿瘤组织 肿瘤发生
分类号 R329.28 [医药卫生—人体解剖和组织胚胎学]
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参考文献28

  • 1Bao R, Connolly DC, Murphy M, et al. Activation of cancer - specific gene expression by the survivin promoter[ J ]. J Nat1 Cancer Inst,2002, 94 (7) :522 - 528.
  • 2Chen YK, Hsue SS, Lin LM. Survivin expression is regulated by an epigenetic mechanism for DMBA - induced hamster buccal - pouch squamous - cell carcinomas [ J ]. Archives of Oral Biology,2005,50 ( 6 ) : 593 - 598.
  • 3Tanaka C, Uzawa K, Shibahara T, et al. Expression of an inhibitor of apoptosis, survivin, in oral carcinogenesis [ J ]. J Dent Res ,2003,82 ( 8 ) : 607 - 611.
  • 4Hattori M,Sakamoto H,Satoh K,et al. DNA demethylase is expressed in ovarian cancers and expression correlates with demethylation of CpG sites in the promoter region of e - erbB - 2 and survivin genes [J]. Cancer Lett,2001,169(2) :155 - 164.
  • 5Esteve PO, Chin HG,Pradhan S. Molecular mechanism of transactivation and doxorubicin - mediated repression of survivin gene in cancer ceils [ J ]. J Biol Chem ,2007,282 (4) :2615 - 2625.
  • 6Xu Y, Fang F, Ludewig G, et al. A mutation found in the promoter region of the human survivin gene is correlated to overexpression of survivin in cancer ceils [ J]. DNA cell Biod ,2004,23 ( 7 ) :419 - 429.
  • 7Wang YH, Chiou HY, et al. Association between survivin gene promoter -31C/G polymorphism and urothelial carcinoma risk in Taiwan Residents population [ J ]. Urology,2009,73 ( 3 ) :670 - 674.
  • 8Li F, Altieri DC. Transcriptional analysis of human surviving gene expression [ J ]. Biochcm J, 1999,344 ( pt 2 ) : 305 - 31l.
  • 9Xu R, zhang P, Huang J, et al. Spl and Sp3 regulate basal transcription of the survivin gene [ J ]. Biochem Biophys Res Commun, 2007,356 ( 1 ) : 286 - 292.
  • 10Chun JY, Hu Y, Pinder E, et al. Selenium inhibition of survivin expression by preventing Spl binding to its promter [ J ]. - Mol Cancer Ther,2007,6(9) :2572 -2580.

二级参考文献15

  • 1朱红霞,王益华,周翠琦,张果,白瑾峰,全兰平,刘芝华,徐宁志.抗凋亡基因survivin在食管癌中的表达及其意义[J].中华肿瘤杂志,2005,27(1):22-24. 被引量：31
  • 2张梅春,胡成平,陈琼.survivin反义寡核苷酸提高人肺腺癌A549耐药细胞系对顺铂敏感性的研究[J].中华肿瘤杂志,2006,28(6):408-412. 被引量：18
  • 3Kayaselcuk F, Nursal TZ, Polat A, et al. Expression of survivin, bcl-2, 1753 and bax in breast carcinoma and ductal intraepithelial neoplasia ( DIN 1 a). J Exp Clin Cancer Res, 2004, 23 : 105-112.
  • 4Morinaga S, Nakamura Y, Ishiwa N, et al. Expression of survivin mRNA associates with apoptosis, proliferation and histologically aggressive features in hepatocellular carcinoma. Oncol Rep, 2004, 12:1189-1194.
  • 5Ikeguehi M, Ueda T, Sakatani T, et al. Expression of survivin messenger RNA correlates with poor prognosis in patients with hepatoceUuar carcinoma. Diagn Mol Pathol, 2002, 11:33-40.
  • 6Qi HL, Zhang Y, Ma J, et al. Insulin/protein kinase B signaling pathway upregulates metastasis-related phenotypes and molecules in H7721 human hepatocarcinoma cell line. Eur J Biochem, 2003. 270:3795-3805.
  • 7Feo F, Pascale RM, Simile MM, et al. Genetic alterations in liver carcinogenesis: implications for new preventive and therapeutic strategies. Crit Rev Oncog, 2000, 11:19-62.
  • 8Deveraux QL, Takahashi R, Salvesen GS, et al. X-linked lAP is a direct inhibitor of cell-death proteases. Nature, 1997, 388:300-304.
  • 9Ambrosini G, Adida C, Ahieri DC. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med, 1997, 3 : 917-921.
  • 10Konminou D, Ayonote A, Richie JP Jr, et al. Insulin resistance and its contribution to colon carcinogenesis. Exp Biol Med, 2003, 228:396-405.

共引文献3

同被引文献22

  • 1Wheatley SP, McNeish IA, Survivin: A protein with dual roles in motisis and apoptosis[J]. International Review of Cytology, 2005; 247:35 - 88.
  • 2Kayaseleuk F, Nursal TZ, Polat A, et al. Expression of surviving, bcl-2, P53 and bax in breast carcinoma and ductal intraepithelial neoplasia (DIN la)[J]. J Exp Clin Cancer Res, 2004; 23(1):105 - 112.
  • 3Beardmore VA, Ahonen L J, Gorbsky G J, et al. Survivin dynamics increases at centromeres during G2/M phase transition and is regulated by mierotubule- attachment and Aurora B kinase activity[J]. Journal of Cell Science, 2004; 117(Ptl 8): 4033 - 4042.
  • 4Otterbach F, Callies R, Adamzik M, et al. Aquaporin 1 (AQP1) expression is a novel characteristic feature of a particularly aggressive subgroup of basal-like breast carcinomas [J]. Breast Cancer Res Treat.2010; 120(1):67-76.
  • 5Pennati M, Folini M. Targeting surviving in cancer therapy: fulfilled promises and questions [ J ]. Carcinegenesis, 2007,28 ( 6 ) : 1133 - 1139.
  • 6Ambrosini G, Adida C, Ahieri DC. A novel anti - apoptosis gene, sur- vivin, expressed in cancel and lymphoma [ J ]. Nat Med, 1997,3 ( 8 ) : 917.
  • 7Shiozakia. Kataokak Suevivin inhibits apoptosis in cytotro phoblast [ J ]. J Placenta, 2003,24: 65.
  • 8Michael S Conte and Dario C Ahieri. Survivin regulation of vascular injury [ J ]. Trends in Cardiovascular Medicine, 2006, 16 (4) : 114 -11.
  • 9Ahemd A, Li XF, Dunk C, et al. Coloca - lisation of vascular endo- thelial growth factor and its Fit - 1 receptor in human placental[J]. Growth Factor, 1997,12:235 - 243.
  • 10刘慧姝,宋小飞,郝荣增.水通道蛋白1在人胎盘和胎膜中的表达[J].南方医科大学学报,2008,28(3):333-336. 被引量：13

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二级引证文献10

现代临床医学
2011年 第2期

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