联合检测LDL-C、GGT在脂肪肝分级中的应用

The Diagnostic Value of Combining Detection of LDL-C with GGT in the Classing of Fatty Liver

目的:探讨LDL-C、GGT等生化指标在脂肪性肝疾病分级中的价值。方法:回顾性分析我院240例住院患者的临床资料,以超声检查为确诊方法,以《中华医学会肝脏病学分会诊疗标准》为金标准。应用方差分析方法比较不同程度脂肪肝患者与正常对照组生化指标LDL-C、GGT的差异,建立各指标诊断轻至中度脂肪肝的ROC曲线。结果:以LDL-C>3.235 mmol.L-1或者GGT>35 U.L-1为阳性并联诊断标准,诊断轻中度脂肪肝敏感度和特异度分别为90.8%及80.0%。结论:联合应用LDL-C、GGT可提高轻至中度脂肪肝诊断的敏感度。

Objective：To explore the diagnostic value of combining detection of LDL-C and GGT in classing of fatty liver. Methods：The results of ultrasonography（USG） and biochemical data of 240 inpatients were collected.Guidelines for diagnosis and treatment of nonalcoholic fatty liver diseases served as the gold standard.ANOVA was used to compare the difference of LDL-C and GGT between patients with fatty liver and healthy controls.ROC curves were used to select the best biochemical indexes to divide the category of fatty lver. Results：Combined the LDL-C with the cutoff values 3.235 mmol·L^-1 or GGT with the cutoff values 35 U·L^-1,the sensitivity and specificity of diagnosis for dividing the middle /slight fatty liver and healthy person were 90 and 69.2 respectively. Conclusion：Combined use of LDL-C with GGT may increase the diagnostic accuracy of mild-moderate fatty liver.