白细胞介素与哮喘发病机制的研究进展

Progress in Interleukin and Pathogenesis of Asthma

支气管哮喘是由多种细胞和细胞因子参与的肺部慢性炎症性疾病,发病机制尚未完全清楚。目前认为,Th1/Th2反应失衡导致Th2细胞过度激活是支气管哮喘重要的免疫学机制之一。现对近年新发现的不同种类的白细胞介素在哮喘发病机制中的作用进行综述,确定了白细胞介素在哮喘发生、发展中的地位,对哮喘的临床实践有一定的指导意义。

Bronchial asthma is a chronic pulmonary inflammatory disease,involving various cells and cytokines.The pathogenesis of asthma is not unclear yet.It is currently recognized that the imbalance of Thl/Th2 response and consequent excessive activation of Th2 cells are one of the important mechanisms of immunology.Now we review the role new interleukins play in the pathogenesis of asthma in these years and the effects of interleukins on the occurrence and development of asthma,helpful for the clinical practice of asthma.