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TGF-β/Smads信号通路及其在肿瘤中的作用 被引量：7

Role of TGF-β/Smads Signaling System in Malignant Tumors
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摘要 活化的转化生长因子β(TGF-β)通过与其受体及胞质蛋白Smads结合转入细胞核内,调节应答基因的转录,TGF-β/Smads信号通路能调节细胞的生长、发育和凋亡。该信号通路在恶性肿瘤的发生、发展过程中起到双重作用,在生理状态下,TGF-β/Smads信号通路具有抑制恶性肿瘤发生的作用;在肿瘤的进展期,反而会促进恶性肿瘤的侵袭和转移。 Activated transforming growth factor beta is translocated into cell nucleus by binding to its receptor and cytoplasic smads,which regulates the transcription of responding genes.TGF-β/Smads signaling system regulates cell proliferation,differentiation,and apoptosis.It plays a dual role in occurrence and progression of malignant tumors.It inhibits the occurrence of early malignant tumor in physiological condition,but promotes the invasion and metastasis of progressive malignant tumor.
作者 李志章 李钦
机构地区 泰山医学院研究生部 临沂市人民医院耳鼻咽喉头颈外科
出处 《医学综述》 2011年第6期847-849,共3页 Medical Recapitulate
关键词 转化生长因子Β SMADS 肿瘤 Transforming growth factor beta Smads Neoplasms
分类号 R735 [医药卫生—肿瘤]
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参考文献22

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二级参考文献29

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共引文献27

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二级引证文献9

医学综述
2011年 第6期

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