圣乔治呼吸问卷在评估中、重度慢性阻塞性肺疾病患者治疗效果中的价值

The value of St george's respiratory questionnaire to assessment therapeutic effect of patients with moderate to severe COPD

目的探讨圣乔治呼吸问卷(SGRQ)在评估中、重度慢性阻塞性肺疾病(COPD)患者治疗效果中的价值。方法选取中、重度COPD患者80例,随机分成沙美特罗替卡松粉吸入剂组及氨茶碱组各40例。每例患者随访4次(为期6个月),每次随访时均要求复查肺功能和调查SGRQ。结果 SGRQ各部分分值间及各部分分值与肺功能(FEV1、FEV1/FVC、FEV1占预计值%)呈负相关,其中活动能力分与总分及肺功能相关性最好,氨茶碱组在治疗前、后分别为-0.418、-0.406,沙美特罗替卡松粉吸入剂组在治疗前、后分别为-0.493、-0.472;在评测治疗效果上,二者均显示沙美特罗替卡松粉吸入剂组优于氨茶碱组(P<0.05)。结论 SGRQ在评测COPD患者治疗效果时,不仅与肺功能及临床症状有很好的相关性,而且还可以较好地反映患者心理变化。

Objective To investigate the value of St george＇s respiratory questionnaire in evaluating therapeutic effect of patients with moderate to severe COPD. Methods 80 patients with moderate to severe COPD were selected. Divided into two groups that ShuLi diego group and aminophylline group,40 cases in each group. Each patient follow-up with 4 times （for six months）. Lung function test and SGRQ were requested in each of the follow up. Results Good correlation （negative） was found in between of each part of the SGRQ score and with lung funetion（FEV1, FEV1/FVC, FEV1pre% ）. The part of Activities was the best of correlation with lung function and total score. In before and after treatment the correlation that the part of activities with lung function and total score, aminophylline group were -0.418 ,-0. 406, ShuLi diego group were-0. 493,-0. 472. The SGRQ and lung function both showed the therapeutic effect of ShuLi diego was Superior of aminophylline（P〈0.05）. Conclusion The SGRQ in evaluating therapeutic effect of patients with moderate to severe COPD, it not only have good correlation with pulmonary function and clinical symptoms, But also can reflect the psychological changes of patients.