48例不同强度光刺激视皮层脑功能成像的临床观察

The study of functional magnetic resonance imaging on different intensity light to stimulate the visual cortex

目的利用功能性磁共振成像(fMRI)研究光强度变化在视皮层的信号强度的反应。方法 48例受试者均接受不同强度白光的刺激。运用功能成像分析AFNI软件对原始数据进行处理,并用统计学方法对图像进行比较。结果 48例受试者接受刺激后在双侧枕叶视皮层均有兴奋区,6 000 mcd强度光刺激的平均BOLD信号强度比4 000 mcd光刺激增强129%(P<0.05),10 000 mcd强度光刺激的平均BOLD信号强度比6 000 mcd光刺激增强63%(P<0.05)。同时发现右侧光刺激的平均BOLD信号强度比左侧增强41%(P<0.05)。此外,脑组织兴奋还见于外侧膝状体、上丘、脑干的顶盖前区、顶叶皮层等。结论通过对fMRI图进行统计学分析,证实在光的刺激下枕叶视皮层血流信号增强,且与强度正相关,并且右侧信号强度变化比左侧强。

Objective To study the change of signal strength of visual cortex that to stimulating it with different intensity light by function MRI. Methods 48 volunteers accepted the stimulation of different intensity light. Functional imaging analysis AFNI software was used for processing the law data, computer automatically generated time signal intensity curves,andusing statistical methods to compare them. Results Occipital lobe in the district on cortex were excited in 48 cases,The average signal intensity of 6000mcd light stimulating than 4000mcd increased 129 %（P〈0.05）. The average signal intensity of 10000mcd light stimulating than 6000med increased 63%（P〈0.05）. The average signal intensity on right was higher than that of left by 41% （P〈0. 05）. It was discovered that other brain excited areas were also found in the corpus geniculatum laterale and Superior colliculus, brain stem of the cap before the area, parietal cortex. Conclusion The statistical analysis of fMRI confirm that the blood flow signals of occipital lobe on cortex is increased through different strength light stimulating, and positively correlate with the intensity of light and change is more occurred in right side thanthat in left side.