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Th17/Treg平衡调节与疾病的关系研究进展 被引量:10

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摘要 机体内初始CD4+T细胞受到外来抗原刺激后,经过增殖并分化为各种效应T细胞,在IL-12和IFN-γ的诱导下分化为Thl细胞,产生IFN-γ,促进机体细胞免疫,从而发挥抗感染、抗肿瘤作用;在IL-4诱导下分化为Th2细胞,分泌IL-4、IL-5和IL-13,介导机体的体液免疫和超敏反应,
出处 《济宁医学院学报》 2011年第1期68-71,共4页 Journal of Jining Medical University
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  • 1Veldhoen M, Hocking RJ, Flavell RA, et al. Signals medated by transforming growth factor beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease[J]. Nat Immunol,2006,7(11) :1151-1156.
  • 2Bettelli E, Carrier Y, Gao Wd, et al. Reciprocal developmental pathways for the generation of pathogenic effeetor Thl7 and regulatory cells[J]. Nature, 2006,441 (7090) : 235-238.
  • 3Korn T,Bettelli E,Gao W,et al. IL-21 initiates an alternative pathway to induce proinflammatory T ( H ) 17 cells [J]. Nature,2007,448(7152) :484-487.
  • 4Nurieva R, Yang XO, Martinez G, et al. Essential autocrine regulation By IL 21 in the generation of inflammatory T cells [J].Nature,2007,448(7152):480-483.
  • 5Zhou L,lvanov II,Spolski R,et al. IL-6 programs T(H) 17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways[J]. Nat lmmunol,2007,8(9):967-974.
  • 6Bettelli E,Oukka M,Kuclaroo VK. TH 17 cells in the circle of immunity and autoimmunity[J]. Nalure Immunology, 2007,8 (4) :345-350.
  • 7Langrish C I.,Chen Y,Blumenschein WM,et al. IL 23 drives a pathogenic T cell population that induces autoimmune in flammation[J]. Exp Med, 2005,201 (2) : 233-240.
  • 8Mangan PR, Harrington LE,O'Quinn DB, et al. Transforming growth factor -βinduees development of the TH17 lineage[J]. Nature,2006,441(7090) :231-234.
  • 9Collison l.W,Workman CJ,Kuo TT,et al. The inhibitory cytokine IL-35 contributes to regulatory T-cell function [J]. Nature,2007,450(22) :566-569.
  • 10Ivanov lI,McKenzie BS,Zhou I.,et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-.17+ T helper eells[J].Cell,2006,126 (6):1121-1133.

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