盆腔孤立性纤维性肿瘤临床病理观察

A clinicopathologic analysis of solitary fibrous tumors in pelvic

目的探讨孤立性纤维性肿瘤(SFT)的病理组织学及免疫组化特点。方法对3例盆腔孤立性纤维性肿瘤病理学分析,用免疫组化方法检测vimentin,CD34,Bcl-2,CD99,CK,SMA,S-100,EMA抗原标记物在肿瘤中的表达情况。结果 3例孤立性纤维性肿瘤光镜下肿瘤细胞由长梭形细胞排列成编织状、束状结构,瘤细胞间有粗细不等的胶原纤维,无特殊的组织构型。免疫组织化学结果Vimentin、CD34、CD99、Bcl-2呈阳性,S-100、EMA、SMA、CK均为阴性。结论 SFT是一组可发生全身各部位形态多样、无特殊组织构型,需与其他梭形细胞肿瘤鉴别,其特殊的免疫表型,有助于本病的诊断。本病多呈良性经过,少数病例具有恶性生物学行为,术后应定期随访。

Objective To discuss pathologic histology and immunologic histochemistry characteristics of solitary fibrous tumor（SFT） in pelvic.Methods Three SFt cases of pelvic received pathologic analysis,antigen markers such as vimentin,CD34,Bcl-2,CD99,CK,SMA,S-100 and EMA were detected by immunologic histochemistry.Results Under optics microscope,tumor cells of three pelvic SFt cases formed intertexture or bunchiness structures by fusiform cells,with unequal collagen fibers among tumour cells,without special tissue configuration.For immunochemistry consequences,vimentin,CD34,CD99 and Bcl-2 were positive,while S-100,EMA,SMA and CK were negative.Conclusions SFt may be found in diversified forms at any site of body but without special tissue configuration,need to differentiate with other fusiform cell tumors.Its special immunological pattern helps to diagnose.Most of SFt show benign behavior,while a few cases have malignant biologic behavior.Thus it is necessary to regular follow-up after operation.