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血管内皮细胞生长因子在类风湿关节炎中的作用 被引量:1

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摘要 血管内皮细胞生长因子(vascular endothelial growth factors,VEGF)是一种多功能性细胞因子,其受体在恶性肿瘤、组织修复和炎性损伤(如类风湿关节炎)的病理和病理生理改变中扮演了极为重要的角色。
作者 刘心悦
出处 《中国冶金工业医学杂志》 2011年第2期146-147,共2页 Chinese Medical Journal of Metallurgical industry
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参考文献6

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同被引文献13

  • 1沙海静,李振彬.活血化瘀法治疗类风湿性关节炎作用机理研究概述[J].中医杂志,2005,46(9):709-710. 被引量:17
  • 2Trentham DE,Townes AS,Kang AH,et al.Autoimmunity to typeⅡCollagen:An experimental model of arthritis[J].J Exp Med,1977,(146):857-868.
  • 3Wakamatsu K,Nanki T,Miyasaka N,et al.Effect of a small molecule inhibitor of nuclear factor-κB nuclear translocation in a murine model of arthritis and cultured human synovial cells[J].Arthritis Res Ther,2005,7(6):1348-1359.
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  • 5Sivakumar B,Akhavani M A,Winlove C P,et al.Synovial hypoxia as a cause of tendon rupture in rheumatoid arthritis[J].The Journal of hand surgery,2008,33(1):49-58.
  • 6Stevens C R,Blake D R,Merry P,et al.A comparative study by morphometry of the microvasculature in normal and rheumatoid synovium[J].Arthritis&Rheumatism,1991,34(12):1508-1513.
  • 7Westra J,Molema G,Kallenberg CG.Hypoxia-inducible factor-1 as regulator of angiogenesis in rheumatoid arthritis-therapeutic implications[J].Curr Med Chem,2010,17(3):54-63.
  • 8Westra J,Molema G,Kallenberg CG.Hypoxia-Inducible Factor-1as Regulator of Angiogenesis in Rheumatoid Arthritis–Therapeutic Implications.Curr Med Chem.2009 Nov 24.[Epub ahead of print].
  • 9Ozgonenel L,Cetin E,Tutun S,et al.The relation of serum vascular endothelial growth factor level with disease duration and activity in patients with rheumatoid arthritis[J].Clin Rheumatol,2010,29(5):473-477.
  • 10J Westra,E Brouwer,et al.Expression and regulation of HIF-1alpha in macrophages under inflammatory conditions;significant reduction of VEGF by CaMKII inhibitor[J].BMC Musculoskeletal Disorders,2010,11:61.

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