服用RU486及米索前列醇作为每月一次避孕药的研究

Onceamonth Treatment with a Combination of RU486 with Misoprostol

本研究旨在观察服用ＲＵ４８６及米索前列醇作为每月一次避孕药的有效性、安全性和可接受性。共接纳２４例对象，观察了８４个周期。用药方案为：预期月经来潮前一日服用ＲＵ４８６２００ｍｇ，４８ｈ后在家中服用米索前列醇４００μｇ。结果显示，妊娠率约为２２．６２％。１９个妊娠周期中有１３个周期完全流产（６８．４２％），２个周期不全流产（１０．５３％），４个周期继续妊娠（２１．０５％）。８４个观察周期中有６个周期出现２次阴道流血，１个周期出现３次阴道流血，７个周期出现周期延长。２４例对象中仅１例因乏力、嗜睡影响工作和生活而退出研究，其余仅极个别对象有恶心、下腹部疼痛、手麻等副反应，但都无需治疗。结果表明用本方案作为每月一次避孕药的效果和可接受性并不理想。

Twentyfour recruited subjects were treated with 200 mg of RU486 in one tablet one day before expected menstruation in combination with 400 μg of misoprostol about 48 hours later in a total of 84 cycles.The results showed that among the 19 pregnancies (22.62%),complete and incomplete abortion occurred in 13 and 2 cycles respectively,while pregnancies still continued in 4 cycles.Among 84 observed cycles,2 bleeding episodes appeared in 6 cycles,3 bleeding episodes in 1 cycle,in addition 7 cycles were prolonged.Only one subject withdrew the study due to weakness and somnolence which influenced her work and life.There were no other serious side effects.The results showed onceamonth treatment with a combination of RU486 (200 mg) and the prostaglandin analogue misoprostol (400 μg) for fertility regulation is unsatisfactory.