盐酸头孢他美酯片在Beagle犬体内的药代动力学研究

Pharmacokinetics of Cefetamet Pivoxil Tablets in Beagle Dogs

目的建立高效液相色谱法测定犬血浆中头孢他美的质量浓度,研究盐酸头孢他美酯片在Beagle犬体内的药代动力学特征。方法予6只Beagle犬单剂量口服250 mg盐酸头孢他美酯片,采用高效液相色谱法测定血浆中头孢他美的质量浓度。结果头孢他美在Beagle犬体内分布符合一室模型,主要药代动力学参数峰浓度(Cmax)为(15.55±6.65)μg/mL,达峰时间(Tmax)为(2.83±0.41)h,半衰期(t1/2)为(1.72±0.41)h,0～24 h药时曲线下面积(AUC0-24)为(61.22±12.39)μg.h/mL。结论所建立的高效液相色谱法简便、快速,可用于体内头孢他美的测定及药代动力学研究。

Objective To establish an HPLC method to detect the concentration of cefetamet in Beagle dog plasma and to study its pharmacokinetics in vivo.Methods The pharmacokinetics of cefetamet in 6 Beagle dogs was studied after oral administration of Cefetamet Pivoxil Tablets 250 mg as single dose.The level of cefetamet in plasma was determined by HPLC.Results The process of cefetamet in Beagle dogs fit the one-compartment model.The main pharmacokinetic parameters were as follows.Cmax was（15.55±6.65）μg/mL,Tmax was（2.83±0.41）h,t1/2 was（1.72±0.41）h,AUC0-24 was（61.22±12.39）μg·h/mL.Conclusion This HPLC method is simple and rapid, which can be applied to the detection and pharmacokinetic study of cefetamet pivoxil in vivo.