奥美拉唑和泮托拉唑钠治疗幽门螺杆菌阳性消化性溃疡的成本-效果分析

Cost-Effectiveness Analysis of Omeprazole and Pantoprazole Sodium for Treating Helicobacter Pylori Positive Peptic Ulcer

目的对奥美拉唑肠溶片和泮托拉唑钠肠溶片治疗幽门螺杆菌阳性消化性溃疡进行药物经济学比较分析,为临床用药提供参考。方法采用回顾性研究法,收集82例幽门螺杆菌阳性消化性溃疡患者并分成两个治疗组,即奥美拉唑组和泮托拉唑钠组,采用统计学研究和成本-效果分析方法进行药物经济学比较。结果奥美拉唑肠溶片和泮托拉唑钠肠溶片对消化性溃疡的总有效率分别为90.00%和88.10%,幽门螺杆菌清除率分别为87.50%和88.10%,治疗成本分别为1 246.33元和1 233.33元,成本-效果比分别为13.85和14.00。结论两组在治疗效果上无明显差异,与奥美拉唑肠溶片相比,泮托拉唑钠肠溶片治疗幽门螺杆菌阳性消化性溃疡略具成本-效果优势。

Objective To perform the comparative analysis on the cost-effectiveness of Omeprazole Enteric Coated Tablets and Pantoprazole Sodium Enteric Coated Tablets for treating Helicobacter pylori（HP）positive peptic ulcer to provide reference for clinical medication. Methods 82 cases of HP positive peptic ulcer were collected and divided into omeprazole group and pantoprazole group by retrospective analysis.The pharmaceutical economics of two groups were analyzed and compared with each other by the statistical and cost-effectiveness methods.Results The effective rates for treating peptic ulcer were 90.00%in Omeprazole Enteric Coated Tablets and 88.10%Pantoprazole Sodium Enteric Coated Tablets and their eradication rates of HP were 87.50%and 88.10%respectively,showing no statistically significant differences（P0.05）.The therapy costs were 1 246.33 Yuan and 1 233.33 Yuan respectively,and their cost-effect ratios were 13.85 and 14.00,respectively.Conclusion The two kinds of enteric coated tablets have no significant difference in the curative effects.Pantoprazole Sodium Enteric Coated Tablets has the cost-effect advantage over Omeprazole Sodium Enteric Coated Tablets in the treatment of HP positive peptic ulcer.