尸体肾移植术后HCMV病的防治

Prophylaxis of HCMV disease for patients undenwent cadaveric renal transplantation

目的探讨尸体肾移植术后人巨细胞病毒（ＨＣＭＶ）病的防治。方法应用ＨＣＭＶＡｇ试验诊断ＨＣＭＶ感染，对１１５０例尸体肾移植进行回顾性分析。结果治疗组：１９８９年９月～１９９７年４月共１０５０例，ＨＣＭＶ病４５例，治愈３０例，死亡１５例；预防组：１９９７年５月～１９９８年５月共１００例，活动性ＨＣＭＶ感染４２例，由于进行了预防性治疗，无１例ＨＣＭＶ病发生和因ＨＣＭＶ感染而死亡。结论ＨＣＭＶＡｇ试验可以早期诊断活动性ＨＣＭＶ感染，指导ＨＣＭＶ病的有效治疗；对活动性ＨＣＭＶ感染积极进行预防性治疗，能显著减少ＨＣＭＶ病的发生。

Objective To study the efficacy of prophylactic therapy of HCMV disease for patients underwent cadaveric renal transplantation. Methods HCMV infection has been detected by means of antigenemia test in 1 150 patients underwent cadaveric renal transplantation and prophylactic management has bee instituted in 42 patients before renal transplantation. Results From Sep.1989 to Apr.1997,HCMV disease was detected after renal transplantation in 45 patients out of 1 050. 30 have been cured of the disease while mortslity occurred in 15 in spite of treatment.From May 1997 to May 1998,active HCMV infection was detected before renal transplantation in 42 out of 100 and appropriate treatment was instituted before transplantation as a prophylactic measure.No HCMV disease occurred after the renal transplantation and there has been no mortatlity because of HCMV disease.Conclusions Detection and treatment of HCMV infection before renal transplantation is very beneficial to the patients and is highly recommended.