大肠息肉患者胸苷激酶检测结果的分析

Analysis on the content of TK1 of patients with colonic polyps

目的通过分析大肠息肉患者胸苷激酶(thymidine kinase,TK1)的含量,探讨TK1在大肠息肉防治中的临床价值。方法对122例大肠息肉患者标本运用化学发光法进行血清TK1检测,同时对息肉黏膜组织切片行TK1病理组化检测。结果大肠息肉组、大肠息肉广基组、息肉多发组的血清TK1水平、血清TK1风险值例数及TK1病理组化阳性数均分别高于健康对照组、有蒂息肉组、单发息肉组,差异有统计学意义(P<0.05,P<0.05,P<0.05);腺瘤组与非腺瘤组比较差异无统计学意义(P>0.05);血清TK1风险组结肠息肉患者与血清TK1健康对照组结肠息肉患者的年龄比较差异具有统计学意义(P<0.05),风险组年龄高于对照组;TK1病理组化方法较检测血清TK1更敏感。结论 TK1浓度检测能真实的评估细胞的增值状态和水平,特别适用于中老年人早期肿瘤风险筛查。

Objective To discuss the clinical importance of the level of thymidine kinase 1（TK1） in preventing colonic polyps.Methods We tested the serum TK1（STK1） of 122 patients with colonic polyps by chemiluminescence,and at the same time tested the polyps mucosa tissue by kinase-1 pathology immunohistochemical.Results The level of STK1,the risk value of STK1 as well as the number of positive immunohistochemistry in colonic polyps patient group,adenomatous polyps patient group,sessile colorectal polyps patient group and ≥2 polyps patient group were significantly higher than those in control group,non-adenomatous polyps patient group,pedunculated colorectal polyps patient group and one polyp patient group（all P〈0.05）.The differences of those parameters between patients with adenomatous polyps and non-adenomatous polyps were not significant（P〈0.05）.The age variation between patients with colorectal polyps who belong to STK1 risk group and patients with colorectal polyps whose STK1 were normal was significant（P〉0.05）.The test of STK1 pathological immunohistochemistry was more sensitive than that of blood serum TK1（P〈0.05）.Conclusion The test of STK1 can actually assess the level of cell proliferation,so it is especially useful for detecting incipient tumors in middle-aged and aged people.