酚磺乙胺注射液与常用制酸药物的配伍稳定性

Study on Compatibility of Combined Use of Etamsylate Injection with Anti-acid Drug

目的研究酚磺乙胺注射液与注射制酸药物的配伍情况,指导临床合理用药。方法参照有关酚磺乙胺注射液与临床常用制酸药物配伍的文献资料,对酚磺乙胺注射液与5种注射制酸药物配伍的理化性质稳定性进行模拟实验。结论酚磺乙胺注射液与泮托拉唑、奥美拉唑制酸药物配伍不稳定,不宜在同一输液器内接触,更不宜混合静脉滴注。酚磺乙胺注射液与雷尼替丁、法莫替丁、西米替丁配伍稳定。

Objective To study the compatibility of etamsylate injection and anti-acid drug, so as to provide reference for the clinical rational usage. Methods Simulated experiment was conducted by wich 5 injectable anti-acid drugs were combined with etamsylate injection separately, to determine the change in physico-chemical properties and the stability. Conclusion Etamsylate injection combined with pantoprazole or omeprazole is not stable, it is not suitable to mix these drugs in the same injector or for intravenous drip. The combination of etamsylate injection with famotidine, ranitidine, or cimetidine is stable.