中西医结合治疗小儿轮状病毒性肠炎72例临床观察

Clinical observation of 72 cases of Chinese medicine combined with western medicine on children with rotavirus enteritis

目的:观察儿茶联合呋塞米、盐酸异丙嗪治疗小儿轮状病毒性肠炎的临床疗效。方法:选择144例轮状病毒性肠炎患儿,按照随机抽样法分成观察组和对照组各72例。2组均给予常规西药抗病毒、补液及对症支持疗法,对照组在此基础上口服思密达,观察组口服中药儿茶、静脉注射呋塞米及盐酸异丙嗪,3 d后观察2组治疗前后主要症状(腹泻呕吐次数、大便性状、发热、脱水程度、心率等)、血常规、血生化指标、大便轮状病毒抗原的变化。结果:观察组临床症状及体征恢复时间较对照组明显缩短,经统计学处理,差异有统计意义(P<0.05或P<0.01);观察组与对照组总有效率分别为88.9%和83.3%,差异有高度统计意义(P<0.05)。结论:在运用西药的基础上加用儿茶、呋塞米、盐酸异丙嗪治疗小儿轮状病毒性肠炎能起到清热利湿的作用,明显缩短病程,并有改善肠外症状的作用,疗效显著。

Objective：To observe the clinical efficacy of combined treatment of catechu and furosemide,promethazine hydrochloride acid on children with rotavirus enteritis.Methods： 144 children patients with rotavirus enteritis were randomly sampled into the observation group and control group,with 72 patients each group.Both the 2 groups were given conventional anti-viral medicine,rehydration and symptomatic and supportive therapy.Besides,the control group was given oral smecta and the observation group was given oral medicine catechu,intravenous furosemide,and promethazine hydrochloride.After 3 days the main symptoms of the observation group before and after the treatment（diarrhea,vomiting frequency,stool,fever,dehydration,heart rate,etc.）,bloodroutine,blood biochemistry,stool rotavirus antigen changes were observed.Results： The clinical symptoms and body sign recovery time were significantly shorter than the control group,the difference was statistically significant（P0.05 or P0.01）.The total effective rate of the observation group and control group was 88.9% and 83.3% respectively,the difference was statistically significant（P 0.05）.Conclusion： In the treatment of children＇s rotavirus enteritis,based on the use of western medicine,additional catechu combined with furosemide and promethazine hydrochloride can play a significant role in clearing away heat,significantly shorten the disease course and improve the intestinal symptoms.