艾司西酞普兰与帕罗西汀治疗抑郁症的临床对照研究

A case-control study of citalopram and paroxetine in the treatment of depression

目的比较艾司西酞普兰与帕罗西汀治疗抑郁症的有效性和安全性。方法将在精神科治疗病例随机分为艾司西酞普兰组和帕罗西汀组,应用汗密顿抑郁量表(HAMD)(17项)评定治疗效果,应用副反应量表(TESS)评定不良反应,在入院时、1、2、4周分别进行对照,分别完成43、44例。结果研究终点两组疗效显示:艾司西酞普兰组有效率为83.7%,帕罗西汀组有效率为86.4%,两组有效率无统计学差异(P>0.05),但艾司西酞普兰起效要快,2周时艾司西酞普兰组的HAMD减分率较帕罗西汀组明显(P<0.05);艾司西酞普兰副作用要少,但共有副作用两者发生率无显著性差异(P>0.05)。结论艾司西酞普兰治疗抑郁症疗效与帕罗西汀相当,但起效要快、不良反应要少,是治疗抑郁症的较好选择。

Objective To explore the validity and safe of Citalopram and Paroxetine in treatment of depression. Methods The cases were divide To into Citalopram group and Paroxetine group at random. Hamilton Rating Scale for Depression and Treatment Emergent Symptom Scale were used to assess the patients with Depressive Disorder. Results There was no significant difference between two groups in the effective power. The Citalopram group got the significantly faster curative effect as compare with the subjects of the Paroxetine group. The Citalopram group had less adverse reaction as compare with the subjects of the Paroxetine group, but the difference was not significant. Conclusion Citalopram has the same curative effect as Pamxetine, but Citalopram has the superiority of earlier curative effect and less adverse reaction than Paroxetine in the Treatment of Depression.