IFN-α治疗小儿乙型肝炎病毒相关性膜性肾病八例报告

Treatment of Hepatitis B Virus-Associated Membranous Nephropathy with Recombinant Human Alpha-Interferon

观察８例小儿乙型肝炎病毒相关性膜性肾病应用ＩＦＮ－α的治疗效果。方法：先给予强的松按１ｍｇ／（ｋｇ·ｄ）治疗 ２周后突然停药，此时开始应用 α－干扰素 １００万 ｕ，隔天 １次肌注，疗程共 ６个月。观察患儿血 ＨＢＶ抗原的转变，尿蛋白及血生化的变化。结果：７例患儿中的４例ＨＢｅＡｇ由阳转阴，８例患儿中的２例ＨＢｓＡｇ由阳转阴， ３例尿蛋白转阴， ３例明显好转，总有效率为 ７５％（６／８）。结论：该剂量疗程的干扰素对小儿乙肝病毒相关性膜性肾病的治疗具有一定效果，适合我国国情，值得推广应用。

To report therapeutical effects of α-interferon on 8 cases of children with hepatitis B virus--associated mem branous nephropathy. Methods:Alpha interferon(IFN-а)was given to every patient at a dose of one million units, intramuscularly,on alternative day for 6 months following prednison 1 mg/(kg·d) for 2 weeks. Urinary protein excretion, serum hepatitis B virus markers and other parameters were observed. Results: HBeAg seroconversion was found in 4 out of 7 children,HBsAg seroconversion in 2 out of 8 cases. Proteinuria became negative in 3 patients, marked improvement in 3 patients. No obvious side effect was found. Conclusion: Alpha interferon treatment is effective on children with HBV-associated membranous nephropathy.