感觉神经肽与支气管反应性关系的研究

Relation of Sensory Neuropeptides to Bronchial Reactivity

用辣椒素耗竭豚鼠离体支气管感觉神经肽（ＳＮＰｓ）后，观察支气管对缺氧及不同化学激动剂的反应变化。结果发现支气管对１０％ 氧产生的舒张反应显著增强（Ｐ＜ ０．０５）； 对１０－ ６ ～２×１０－ ４ ｍ ｏｌ／Ｌ组胺（Ｈｉｓ）及１０－ ５ ～１０－ ４ ｍ ｏｌ／Ｌ５－羟色胺（５－ＨＴ） 的收缩反应显著降低（均为Ｐ＜ ０．０５）， 而对１０－ ６ ～２×１０－ ４ ｍ ｏｌ／Ｌ乙酰胆碱（ Ａｃｈ） 的收缩反应和异丙肾上腺素 （Ｉｓｏｐ） 的舒张反应均无明显改变。提示支气管Ｃ－感觉神经所释放的ＳＮＰｓ降低支气管对缺氧的反应性，增强对Ｈｉｓ和５－ＨＴ的反应性， 但不影响其对Ｉｓｏｐ 和Ａｃｈ 的反应性。

After depleting the sensory neuropeptides ( SNPs) with capsaicin,the changes in the reaction of the guinea pig bronchi to 10% oxygen and to different agonists were observed in vitro. The results showed that the relaxant reaction of the bronchi to 10% oxygen was increased, and their responses to histamine (His, 10 -6 ～2×10 -4 mol/L) and serotonin (5-HT, 10 -5 ～10 -4 mol/L) decreased ( P <0 05), while the responses to acetylcholine (Ach) and isoproterenol( Isop) remained unchanged ( P >0 05). It is suggested that SNPs released from C sensory nerves in bronchi could reduce the bronchial reactivity to hypoxia and potentiate that to His and 5 HT, but they had no influence on the brochial reactivity to Ach and Isop.