摘要
为明确克雷伯杆菌对临床常用抗菌药物的敏感性, 收集了1996年度武汉市13 家大中型医院住院免疫低下患者体内分离的克雷伯杆菌, 并用琼脂板稀释法测定16 种抗菌药物的最低抑菌浓度。结果共得细菌152 株, 以肺炎克雷伯杆菌为主 (128 株), 尚有臭鼻克雷伯杆菌 (13株)、催产克雷伯杆菌 (9 株)、鼻硬结克雷伯杆菌 (2 株)。药敏测定表明: β-内酰胺类中除头孢他啶、依米配南的MIC90≤16 μg/m l, 其它对克雷伯杆菌的MIC90 均较高, 但阿米卡星、环丙沙星的MIC90仅为8 和1 μg/m l。臭鼻和催产克雷伯杆菌对部分抗菌药物的耐药性高于肺炎克雷伯杆菌。比较不同部位分离的肺炎克雷伯杆菌药敏,结果表明:非呼吸道分离的肺炎克雷伯杆菌对药物的敏感性总体上低于呼吸道分离的菌株。
To understand the resistance and susceptibility of Klebsiella spp to common antimicrobial agents, all of Klebsiella spp from the immunocompromised hospitalized patients in 13 hospitals in Wuhan were collected during 1996, and their MIC for 16 antimicrobial agents were assayed by agar dilution plate method. 152 strain of Klebsiella, which consisted of K. pneumoniae (128),K. ozaenae (13) and K. oxytoca (9), were obtained. As a result of drug sensitive test, a low MIC90 (≤16 μg/ml) was discovered for CAZ, IPM, AMK and CIP, but other antimicrobial agents showed a high MIC90 value. The resistance of K. ozaenae and K. oxytoca to some agents was higher than that of K pneumoniae. This study also suggested that K. pneumoniae isolated from the respiratory tracts are less resistant than that from the other lesions in principle.
出处
《同济医科大学学报》
CSCD
1999年第4期356-358,共3页
Acta Universitatis Medicinae Tongji
基金
卫生部国际交流中心-默沙东基金
关键词
克雷伯杆菌
药敏试验
最低抑菌浓度
抗菌药
Klebsiella spp
\ drug sensitive test
\ minimal inhibitory concentration