小涎腺肌上皮癌临床病理分析

Clinicopathological analysis of myoepithelial carcinoma of minor salivary glands

目的:探讨小涎腺肌上皮癌的临床病理特点。方法:对9例小涎腺肌上皮癌组织进行HE染色和免疫组织化学染色,并进行回顾性分析。结果:病理检查光镜下肿瘤呈多结节状、片状、小梁状或小巢状生长;肿瘤细胞以上皮细胞样和透明细胞多见;可见肿瘤性基质沉积,其中玻璃样基质较黏液基质更多见。免疫组织化学示CKAE1/AE3,S-100、波形蛋白,P63和maspin在所有肿瘤中弥漫阳性表达,4例SMA呈阳性表达。5例患者获随访资料,术后均无局部复发或转移。结论:小涎腺肌上皮癌为低度恶性涎腺肿瘤,不易发生淋巴结和远处转移。确诊需结合组织学和免疫组织化学。

Objective： To investigate the clinicopathological features of myoepithelial carcinoma of minor salivary glands.Methods： Nine samples of myoepithelial carcinomas of minor salivary glands were stained by HE staining and immunohistochemical method,then were analyzed retrospectively.Results： Light microscope showed that the tumors exhibited a solid architecture with cells arranged in nodules,nests,trabeculae,or cords.The epithelioid cell type was the most frequently encountered,followed by clear cells. The tumor-associated hyalinized matrix was more prevalent than myxoid. Immunohistochemieal analysis showed that CK AE1/AE3, S]00, vimentin, p63, and maspin were expressed in all cases. Positive SMA was seen in 4 cases, and 5 patients with follow-up information showed no evidence of disease. Conclusions： Myoepithelial carcinoma of minor salivary glands is generally a low-grade malignant tumor with little propensity for regional or distant metastasis. Clinicopathologieal and immunohistochemieal analysis is necessary for accurate diagnosis.